Gene Reporter Systems
Enzo Life Sciences AMPINEXT™ High-Sensitivity Bisulfite-Seq Kit (Illumina) (24Reactions)
The AMPINEXT™ High-Sensitivity Bisulfite-Seq Kit (Illumina) is designed to bisulfite-convert DNA and prepare an Illumina-based library for bisulfite sequencing, all in one kit. Intended applications include whole genome (WGBS), oxidative (oxBS-seq), reduced representation (RRBS), and other bisulfite-next generation sequencing. The optimized protocol and components of the kit allow subnanogram amounts of DNA to be bisulfite converted and fragmented simultaneously followed by quick non-barcoded (singleplexed) and barcoded (multiplexed) library construction in less than 7 hours. Assay Time: <7 hours.
Genscript Corporation VEGF R2/KDR mFc Chimera Human
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA VEGFB and PGF and plays an essential role in the development of embryonic vasculature the regulation of angiogenesis cell survival cell migration macrophage function chemotaxis and cancer cell invasion The tyrosine kinase receptor vascular endothelial growth factor receptor 2 (VEGFR2) is a key regulator of angiogenesis
Biotium Steady-Luc™ Firefly HTS Assay Kit, Trial Size, 40 Assays
Biotium’s Steady-Luc™ HTS assay system is a proprietary mixture of substances that modify the enzymatic reaction to produce a long lasting signal (steady glow) by preventing the formation of adenyl-oxyluciferin at the enzyme surface. It is a single-step, homogeneous, high sensitivity firefly luciferase reporter gene assay kit with a half-life of about 3 hours for the quantification of firefly luciferase expression in mammalian cells, allowing batch processing in microplates. Glow-type luciferase assays like Steady-Luc™ have lower luminescence signal compared to flash-type assays. The sensitivity and limit of detection of the assay will depend on luciferase expression levels in your experimental system as well as luminometer sensitivity. The kit is a trial size version and has reagents sufficient for 40 assays in a 96-well format.
Biotium Steady-Luc™ Firefly HTS Assay Kit, 120 Assays
Biotium’s Steady-Luc™ HTS assay system is a proprietary mixture of substances that modify the enzymatic reaction to produce a long lasting signal (steady glow) by preventing the formation of adenyl-oxyluciferin at the enzyme surface. It is a single-step, homogeneous, high sensitivity firefly luciferase reporter gene assay kit with a half-life of about 3 hours for the quantification of firefly luciferase expression in mammalian cells, allowing batch processing in microplates. Glow-type luciferase assays like Steady-Luc™ have lower luminescence signal compared to flash-type assays. The sensitivity and limit of detection of the assay will depend on luciferase expression levels in your experimental system as well as luminometer sensitivity. The kit has reagents sufficient for 120 assays in a 96-well format.
Cayman Chemical PDGFR TKI III 5mg
A PDGFRα and PDGFRβ inhibitor (IC50s = 0.05 and 0.13 µM, respectively); selective for PDGFRα and PDGFRβ over FGFR, EGFR, PKA, and PKC (IC50s = 29.7, >30, >30, and >30 µM, respectively) but does inhibit c-Kit and FLT3 (IC50s = 0.05 and 0.23 µM, respectively); inhibits PDGF homodimer-induced proliferation of pig aorta smooth muscle cells (IC50 = 0.25 µM); inhibits the migration of primary mouse DA-MSCs induced by embryonic mouse blood at 2 µM
Cell Signaling Technology PathScanR RP Total TrkA Sandwich ELISA Kit 10 Kit
PathScanR RP Total TrkA Sandwich ELISA Kit 10 Kit
ABclonal Technology PKC alpha Rabbit pAb
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes.
Cayman Chemical PKC SubstrATtrIfluoroacet 10mg
A peptide substrate for PKCδ; has been used to monitor PKCδ activity in cell-free and cell-based assays
ABclonal Technology PE anti- CD140b/PDGFR beta
Enables platelet-derived growth factor-activated receptor activity and signaling receptor binding activity Involved in several processes including positive regulation of intracellular signal transduction protein phosphorylation and vasculature development Acts upstream of or within several processes including animal organ development response to ceramide and ruffle assembly Located in cell surface cytoplasm and ruffle Is expressed in several structures including alimentary system extraembryonic component genitourinary system nervous system and sensory organ Used to study basal ganglia calcification infantile myofibromatosis myeloproliferative neoplasm and severe nonproliferative diabetic retinopathy Human ortholog(s) of this gene implicated in basal ganglia calcification glioblastoma infantile myofibromatosis myeloproliferative neoplasm (multiple) and renal cell carcinoma Orthologous to human PDGFRB (platelet derived growth factor receptor beta)
![ABclonal Technology [KO Validated] ROCK1 Rabbit pAb](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000137376.jpg-250.jpg)
ABclonal Technology [KO Validated] ROCK1 Rabbit pAb
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.